Issue 
Acta Acust.
Volume 7, 2023



Article Number  21  
Number of page(s)  11  
Section  Hearing, Audiology and Psychoacoustics  
DOI  https://doi.org/10.1051/aacus/2023017  
Published online  26 May 2023 
Scientific Article
Parametric model of young infants’ eardrum and ear canal impedances supporting immittance measurement results. Part II: Prediction of eardrum and ear canal impedances for frequent pathological middle ear conditions
^{1}
Institut für Hörtechnik und Audiologie, Jade Hochschule, Ofener Str. 16/19, 26121 Oldenburg, Germany
^{2}
Acoustics Group, Carl von Ossietzky Universität Oldenburg, CarlvonOssietzkyStr. 911, 26129 Oldenburg, Germany
^{3}
Cluster of Excellence “Hearing4All”
^{*} Corresponding author: tobias.sankowsky@jadehs.de
Received:
21
April
2022
Accepted:
25
April
2023
In order to gain a better understanding of wideband acoustic immitance (WAI) measurements, in this second part of a twopart paper, the parametric electroacoustic model of the ear canal and the middle ear of young infants proposed in the first part is extended. The extension allows predictions of the influence of the pathological middle ear conditions middle ear effusion and negative static air pressure difference between the middle ear and the ear canal. Comparisons of the acoustic input impedance of the ear predicted by the model with real ear measurements in young infants’ ears with middle ear effusion show that the effects due to the pathology can be predicted well. For the negative static air pressure, a modeling approach was proposed but could not be confirmed yet, due to a lack of available measurement data. Furthermore, comparisons between different middle ear states (healthy, middle ear effusion and static air pressure difference) predicted by the model showed characteristic differences in all relevant WAI measures. However, it is also shown that WAI measures requiring an estimate of the crosssectional area at the measurement position, i.e., absorbance and reflectance, are highly sensitive to this estimate.
Key words: Acoustic impedance / Absorbance / Middle ear / Outer ear / Screening
© The Author(s), published by EDP Sciences, 2023
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
1 Introduction
The aim of this work is to investigate the use of the model presented in [1], which predicts wideband acoustic immitance (WAI) measured within the ear canal, for detecting certain pathological middle ear conditions in young infants. WAI comprises measures like the acoustic impedance, the acoustic admittance, as well as measures derived from these quantities like the reflectance or the absorbance. WAI has been identified to be a promising tool in middle ear diagnostics [2]. In this context it is important to note that several properties of the ear canal and the middle differ between young infants on the one hand and older children and adults on the other hand, resulting in significantly different WAI results [1].
In the accompanying paper [1], a parametric electroacoustic model of the ear canal and the middle ear of healthy young infants was proposed. The model parameters represent physiological properties wherever possible. The model was used to predict the ear canal acoustic impedance Z_{ec}, the quantity which is measured in a WAI measurement, and the acoustic input impedance at the eardrum Z_{D}, the interesting quantity in terms of middle ear diagnostics which can, however, not directly be measured. In the model, Z_{D} is defined to be the acoustic input impedance of the middle ear including the eardrum. Z_{ec}, on the other hand, is defined to be the quotient of the sound pressure to the volume velocity at the measurement position in the ear canal. Three main findings were identified in the study.
The soft and flexible ear canal walls in young infants’ ears affect Z_{ec} up to about 1.5 kHz with no significant effect for higher frequencies.
At medium frequencies around 1.8 kHz, Z_{ec} is dominated by the input impedance at the eardrum Z_{D}. Thus, the largest effects of pathological middle ear conditions on Z_{ec} is expected at medium frequencies.
At high frequencies, the model prediction of Z_{ec} has a much smaller magnitude compared to Z_{D} indicating that Z_{ec} is dominated by ear canal properties and therefore, it might be difficult to detect different middle ear conditions at these frequencies. However, the predictions must be taken with caution at high frequencies because many measurements on real ears showed higher Z_{ec} magnitudes than the predictions. The relatively smaller difference between the measured Z_{ec} magnitudes and Z_{D} could mean that in some cases middle ear conditions could still be detected.
The objectives of the present paper are a) the extension of the model in order to predict the influence of different pathological middle ear conditions on the acoustic input impedances of the ear canal and the eardrum, and b) the investigation of implications for WAI measurements. Two pathological middle ear conditions have been chosen for the model extension:
Firstly, middle ear effusion, resulting from otitis media, is the most frequent pathological middle ear condition in young infants with prevalence rates of 74% found in [3] for children in the first 6 months of life and 48.8% found in [4] for children aged between 2 and 6 months.
Secondly, a negative static air pressure difference between middle ear and ear canal will be considered. It is often one of the earlier symptoms of otitis media (see e.g.[5, 6]).
The model predictions will be compared with ear canal acoustic impedances measured in infant ears published in [7]. The aspects of the measurement procedure relevant for this study will be described here in detail. As described in [1], the measurement method is based on [8], extended by consideration of discontinuity and end corrections in [9]. The method including the calibration procedure is described in detail in [9]. The measurements were performed using a custommade impedance probe to measure the ear canal impedance on infant ears. The probe was designed to avoid overpressure in the ear canal caused by inserting it into the ear canal at the cost of a decreased signaltonoise ratio (SNR) at frequencies below about 1 kHz, further details can be found in [7]. This was realized by a pressure equalizing duct with an inner diameter of 0.6 mm.
The subjects who participated in the study were aged between 2 weeks and 5 months. It should be noted that the infant ear undergoes developmental changes within the age range of the participants, i.e. an agerelated effect is contained in the measurement data. The middle ear status of the participants was assessed by ENTdoctors specialized in pediatric audiology to be either normal, pathological or unclear at the time of testing. The assessment was based on the results of 1 kHz tympanometry, OAE and/or AABRscreening, and earmicroscopy (see again [7] for details). While in [1] the measurement data of the ears that were assessed to have a normal middle ear status were used, in this paper, we concentrate on the ears that were assessed to have a pathological middle ear status. This comprised 13 ears from 9 infants.
Models predicting the effects of fluid in the middle ear have been proposed in [10] and [11]. In contrast to the present paper, both models differ in the modeling approach and in the targeted age. In [10], a finiteelement model of an adult ear was presented and in [11] a finiteelement model of the ear of an infant aged 4 years was presented. It is known from literature, that the acoustic input impedance of the ear significantly differs between those ages and the age range from 0.5 to 5 months, which is addressed here (see e.g. [12]).
The paper is organized as follows. In Sections 2 and 3, the model extensions and comparisons of predicted and measured Z_{ec} are given for the conditions of fluid in the middle ear and negative pressure difference between the ear canal and the middle ear, respectively. In Section 4, model predictions for normal and pathological middle ear conditions are compared for various WAI measures. In Section 5, implications for WAI measurements are given. A MATLAB implementation of the model can be found in [13].
2 Predicting the effect of fluid in the middle ear
Fluid in the middle ear may occur as remaining amniotic fluid after birth or as middle ear effusion. In both cases, a substantial part of the middle ear cavities is filled with liquid, covering partly the eardrum.
The representation in the model should comprise a reduced volume of the tympanic cavity, resulting in a smaller value of the acoustic compliance of the tympanic cavity N_{tcav}, and a reduced area of the eardrum that is vibrating, resulting in modified values of the effective eardrum area A_{0}, the eardrum acoustic shunt impedance Z_{ac}, and the mechanical eardrum parameters, namely the mechanical mass and resistance of the free vibrating portion of the eardrum m_{free} and w_{free}.
A first approach to implement the effect of fluid in the middle ear is proposed as follows: The effective eardrum area is decreased using a factor x_{A} < 1, such that
According to [1] (Eq. 21)
(2)the eardrum acoustic shunt impedance Z_{ac} is determined by the acoustic compliance N_{ac}, the acoustic mass M_{ac} and the acoustic resistance W_{ac}. For simplicity it is assumed that the eardrum geometry remains circular when the area is decreased, i.e., only the radius of the vibrating membrane is reduced by . From [1] (Eq. 22),
(3)with a_{ed} the radius of the eardrum, T_{0,ed} the eardrum tension and h_{ed} the thickness of the eardrum, one can infer that the acoustic compliance should change with , i.e. the acoustic compliance decreases if the eardrum area decreases. The acoustic mass should then change with 1/x_{A} according to [1] (Eq. 23),
(4)with ρ_{ed} the membrane mass density, i.e. the acoustic mass increases if the eardrum area decreases. Because a simple relation between the acoustical resistance and the area of the eardrum is not known, in a first approach W_{ac} is kept constant. The mechanical mass of the free vibrating part of the eardrum m_{free} is changed by multiplying it with x_{A} assuming that the free vibrating portion of the eardrum decreases with x_{A}. A relation between the eardrum area and the mechanical resistance w_{free} is not known, therefore the value is kept constant.
The volume change of the tympanic cavity can also be linked to the parameter x_{A}, by letting
(5)effectively assuming that the volume of the tympanic cavity results from protruding the reduced area of the vibrating eardrum.
The impact of different values of x_{A} on the acoustic input impedance at the eardrum Z_{D} and the eardrum acoustic shunt impedance Z_{ac} is depicted on the left side of Figure 1. It can be seen that the smaller the eardrum area gets, the more Z_{D} is dominated by Z_{ac}. Furthermore, a smaller eardrum area shifts the magnitude minimum and the phase change to higher frequencies. At frequencies smaller and larger than the minimum, the magnitude increases with decreasing eardrum area.
Figure 1 First approach to model the effects of fluid in the middle ear. Left: Acoustic input impedance at the eardrum Z_{D} and eardrum acoustic shunt impedance Z_{ac} for different factors of eardrum area. Middle: Ear canal impedance for different factors of eardrum area resulting from the model using an ear canal radius of 1.7 mm and an ear canal length of 14 mm. Right: Ear canal impedances measured in infants’ ears with middle ear effusion from [7]. 
In the middle column of Figure 1, the ear canal impedance Z_{ec} is depicted for different values of x_{A}. The ear canal is modeled using a constant ear canal radius of 1.7 mm and an ear canal length of 14 mm. In the right column of Figure 1, measurement results from [7] of ear canal impedances measured in infants’ ears with diagnosed middle ear effusion are depicted. The measurements suffer from a bad signaltonoise ratio (SNR) at low frequencies, therefore, only those values are depicted in which the coherence between the signal applied to the probe speaker and the signal sensed by the probe microphone exceeded 0.5. Another effect that is present in the majority of the measurements is acoustic leakage resulting in an impedance magnitude increasing with increasing frequency and positive phase values up to about 2 kHz. In the modeling, a tightly sealed ear canal is assumed, i.e. without leakage, therefore, in the following comparisons between measurements and predictions concentrate on higher frequencies, while differences up to about 2 kHz are ignored. The predicted shift of the first magnitude minimum below 2 kHz to higher frequencies is well reflected in the measurements. Above this first minimum, there is a mismatch between model and measurements. In the model output, the second minimum, which is mainly determined by the ear canal geometry, is only weakly affected by the variation of x_{A}. In the measurements, however, no second minimum can be seen up to 10 kHz. The only magnitude minimum in the measurements is broader than the first minimum of the model. It is located at lower frequencies than the second minimum of the model.
Based on these observations, the previously described approach of modeling the effects of fluid in the middle ear is amended. Firstly, in order to obtain a greater shift of the magnitude minimum of Z_{ac}, the acoustic mass M_{ac} is not changed with changing x_{A},which can be interpreted as the acoustically effective part of the vibrating mechanical mass of the eardrum being proportional to instead of x_{A}, which was expected in the first place. Secondly, the acoustic resistance W_{ac} is decreased with decreasing x_{A}, using
The result of this final approach used to model the effects of fluid in the middle ear can be seen in Figure 2. Again, on the left side the acoustic input impedance at the eardrum Z_{D} and the eardrum acoustic shunt impedance Z_{ac} are depicted for different eardrum area factors x_{A}. The differences compared to the first approach are a shift of the magnitude minimum to higher frequencies and a smaller value of the impedance at the minimum, both for x_{A} < 1. In the middle column, the ear canal impedance Z_{ec} of the model for different factors of x_{A} can be seen. For a factor x_{A} = 0.18 it can be seen that the course of the impedance is very similar to that of the measurements at high frequencies, which are depicted in the right column of Figure 2. At about 5 kHz, there is a magnitude minimum and a phase increasing with frequency with a slope much like the measurements. A further minimum appears at a frequency slightly smaller than 10 kHz which is a little less than in the measurements. If the eardrum area is further decreased, both minima are shifted to higher frequencies. It can be concluded that the distance between the two minima at high frequencies might be a little underestimated, but an eardrum area decreased by a factor of about 1/5 results in a good estimation of the effects of fluid in the middle ear. This can be seen in Figure 3 in which the prediction of Z_{ec} using a factor x_{A} = 0.2 is depicted together with all measured impedances of infant’s ears with middle ear effusion from [7].
Figure 2 Final approach to model the effects of fluid in the middle ear. Left: Acoustic input impedance at the eardrum Z_{D} and eardrum acoustic shunt impedance Z_{ac} for different factors of eardrum area. Middle: Ear canal impedance for different factors of eardrum area resulting from the model using an ear canal radius of 1.7 mm and an ear canal length of 14 mm. Right: Ear canal impedances measured in infants’ ears with middle ear effusion from [7]. 
Figure 3 Final approach to model the effects of fluid in the middle ear. Ear canal impedance for a factor of x_{A} = 0.2 eardrum area resulting from the model using an ear canal radius of 1.7 mm and an ear canal length of 14 mm together with all ear canal impedance measurements on infants’ ears with middle ear effusion from [7]. 
3 Predicting the effect of negative pressure difference between the middle ear cavities and the ear canal
Due to a dysfunction of the eustachian tube and the gas resorption of the mucosa, the static pressure of air in the middle ear cavities p_{0,ME} can be decreased. Compared to the ambient static pressure of air p_{0}, the pressure difference Δp_{0} = p_{0,ME} − p_{0} gets negative. Consequences of the negative Δp_{0} are a retracted eardrum with an increased tension of the membrane, a reduced density of air in the middle ear cavities, and a slightly decreased volume of the tympanic cavity. A relevant range of Δp_{0} can be obtained from the measurement range in tympanometry, which reaches down to −400 daPa (−4 kPa).
In the model, the tension of the eardrum is represented in the acoustic compliance N_{ac} which is part of the eardrum acoustic shunt impedance Z_{ac}. As described in part I ([1], Sect. 2.2.3), Z_{ac} is modeled as a stretched circular membrane [1]. According to [14] (p. 68), the displacement ξ_{z} orthogonal to the membraneplane due to a pressure difference Δp_{0} at a normalized radial distance from the center r/a is given by
(7)with T_{0} the tension of the nondisplaced membrane and h the membrane thickness. Therefore, the displacement at the center of the membrane is given by
The membrane takes the shape of an elliptical paraboloid. The area of the membrane with the displacement ξ_{z}(0) is given by
(9)corresponding to an area of a circle with a radius of
The inmembrane strain S for a given displacement ξ_{z}(0) is given by
(11)resulting, by using equations (8) and (10), in
With the relation between strain and tension of the membrane given in [14]
(13)with Young’s modulus E and Poisson’s ratio ν, the membrane tension for a static Δp_{0} can be calculated using
The acoustic compliance of the displaced membrane is then given by
(15)with the thickness of the stretched eardrum. If an incompressible isotropic medium of the membrane (ν = 0.5, see e.g. [15]) is assumed, the volume of the membrane remains unchanged. With equation (11), the thickness of the stretched eardrum is given by
As mentioned above, the negative pressure difference affects the middle ear cavities by decreasing the density of air in the middle ear, and by decreasing the volume of the tympanic cavity. The decrease in density of air in the middle ear cavities increases the compliance of the tympanic cavity N_{tcav} and the compliance of the antrum N_{ant}. The density is given by
The volume occupied by the statically displaced membrane, i.e. the volume decrease of the tympanic cavity, is given by
Both effects, the decrease of ρ_{me} and the decrease of V_{tcav} are very small. Especially the resulting change of the compliance of the tympanic cavity, given by N_{tcav} = V_{tcav}/(ρ_{me}c^{2}) with the speed of sound c, is small because the volume change decreases the numerator whereas the density change decreases the denominator.
The only parameter value needed to model a negative pressure difference between the middle ear cavities and the ear canal, is the Young’s modulus E of the membrane (see Eq. (15)). Note that Poisson’s ratio ν was already chosen to be 0.5. Unfortunately, there is no easy way to determine E. In the literature, values of Young’s modulus of real tympanic membranes can be found, at least for adult ears. However, those values cannot be used directly for the modeling approach of a stretched circular membrane because of the different membrane shapes and inplane tensions. This means that a value of E could only be determined indirectly, e.g. from impedance measurements at different strain levels. It would, however, be necessary that the effect of membrane stress could be separated from other effects like e.g. those caused by compliant ear canal walls in tympanometry. To the best of our knowledge, no studies exist in which the effect of negative pressure difference in young infants’ middle ears on immittance measurements is investigated independently of the influence by the soft and flexible ear canal walls. Therefore, we had to estimate a resonable value of E. Assuming that E has a substantial effect on Z_{D} for Δp_{0} in the range from 0 to −2.5 kPa, we chose a value of E = 100 MPa. On the left side of Figure 4, both, the eardrum acoustic shunt impedance Z_{ac}, and the acoustic input impedance at the eardrum Z_{D} are depicted for different Δp_{0}. As can be seen, the minimum in the magnitude of Z_{ac} shifts to higher frequencies when Δp_{0} is decreased from zero to negative values. This can also be observed for the global minimum in Z_{D}. If the minimum in Z_{ac} is shifted to higher frequencies, a new magnitude minimum in Z_{D} at about 800 Hz emerges followed by a maximum at about 1.2 kHz. This minimum is caused by the mechanical middle ear components, in particular by the ossicles. The ear canal impedance Z_{ec} of the model is depicted on the right side of Figure 4. Additionally, measurements from [7] on infants’ ears where the tympanometric peak pressure was smaller than −1 kPa (−100 daPa) are depicted, unfortunately, there where only two ears in which this was clearly the case. As can be seen in the magnitude, a local maximum appears at about 1.1 kHz if Δp_{0} gets negative. This can also be observed in the measurements. In the phase of Z_{ec}, the increase with frequency between 1.2 kHz and 2.5 kHz is shifted to higher frequencies with a steeper slope for negative Δp_{0}. Regarding the modeling approach, an assessment of the choice of parameters is not possible at this time due to a lack of available measurement data, therefore, it can only be seen as a first proposal. However, the resulting effects show at least some similarities with the few measurements.
Figure 4 Modeling of the effect of negative pressure difference between ear canal and middle ear using a Young’s modulus of E = 100 MPa. Left: Acoustic input impedance at the eardrum Z_{D} and eardrum acoustic shunt impedance Z_{ac} for different pressure differences Δp_{0} in kPa between ear canal and middle ear. Right: Ear canal impedance for different pressure differences Δp_{0} in kPa resulting from the model using an ear canal radius of 1.7 mm and an ear canal length of 14 mm, together with ear canal impedances from [7] measured in infants’ ears where the tympanometric peak pressure was smaller −1 kPa (−100 daPa). 
In summary, an approach to model the effect of negative pressure difference between the middle ear cavities and the ear canal was proposed. However, there are several simplifications in the modeling approach. First of all, using a stretched circular membrane is obviously a significant simplification, which among other things has the consequence that a physiologically correct value of Young’s modulus cannot be used. Furthermore, the assumption of the eardrum behaving linearelastically may not fully hold in practice, even in the range of typically observed tympanometric pressures. Despite these assumptions some characteristics observed in the few available measurements are captured by the model. More data involving negative tympanic pressures would be required for a more indepth validation.
4 Comparison of immittance measures for normal and pathological middleear conditions
There is an ongoing discussion of the suitability of different immittance measures for screening or diagnostic purposes of young infants’ middle ears. All these measures are derived from the acoustic impedance in the ear canal (Z_{ec}) or its reciprocal, the acoustic admittance. Most investigations concentrate either on the energy reflectance (also called power reflectance) which is given by R^{2} = (Z_{ec} − Z_{tw})/(Z_{ec} + Z_{tw})^{2}, with the tube wave impedance Z_{tw} of the ear canal crosssection at the measurement position, or on the energy absorbance given by 1 − R^{2}. Sometimes, the phase or group delay of the pressure reflectance R is also discussed [16, 17].
The model output for different immitance measures is depicted in Figure 5 for three different states of the middle ear, namely normal, fluid in the middle ear (x_{A} = 0.2), and a negative pressure difference of Δp = −2500 Pa between the middle ear cavities and the ear canal. In the left column, the acoustic input impedance at the eardrum (Z_{D}) is depicted. Z_{D} directly reflects the state of the middle ear and hence is the desired measure, however, it is not directly available. In the second column of Figure 5, the acoustic input impedance (Z_{ec}) is depicted as it would be measured in the ear canal. The complexvalued pressure reflectance R is depicted in the third column with its magnitude (top) and its group delay (bottom). Finally the energy reflectance is depicted in the top and the energy absorbance in the bottom panel of the last column. All of the selected immitance measures show characteristic differences between the three states.
Figure 5 Comparison of predicted immittance measures for ears with normal middle ear, fluid in the middle (x_{A} = 0.2), and negative pressure difference between middle ear and ear canal (Δp = −2500 Pa). Left column: acoustic input impedance at the eardrum; second column: input impedance of the ear; third column: magnitude and group delay of the reflectance; right column top: energy reflectance; right column bottom: energy absorbance. 
The most important changes compared to the normal middle ear condition in the case of fluid in the middle ear are a massively increased magnitude of ZD up to a frequency of 6 kHz and a large difference in the phase of ZD between 1.5 kHz and 8 kHz. The magnitude of Z_{ec} differs largely between 500 Hz and 2 kHz where a local maximum appears and at high frequencies due to a shift of the minimum to lower frequencies. The phase of Z_{ec} has a significantly different slope at frequencies higher than 500 Hz. The magnitude of the reflectance is much larger at frequencies between 500 Hz and 5 kHz and the group delay has significantly smaller values between about 1 kHz and 3 kHz.
In the case of a negative pressure difference between middle ear and ear canal, the magnitude of Z_{D} is significantly larger between 900 Hz and 2 kHz. The phase of Z_{D} has a local maximum at 900 Hz and the phase change in midfrequency range is shifted to higher frequencies. The magnitude of Z_{ec} has a conspicuous maximum at 1.1 kHz and the phase of Z_{ec} has smaller values between 1.1 kHz and 3 kHz. The magnitude of the reflectance has a peak at 1.2 kHz and a minimum at 3 kHz. The group delay does not show the maximum at 1.7 kHz.
In conclusion, all of these quantities should be included in the search for an objective classification of midleear disorders in humans. This is particularly true for phase (or alternatively, group delay) quantities, which have mostly been ignored so far.
Measurementbased data of the mean energy absorbance for age groups between 1 and 3 months have been published in [12, 18, 19, 17]. In Figure 6 these data are depicted with thin lines together with the energy absorbance predicted by the model (thick lines) using three different areas to compute the tube wave impedance: 1) the correct ear canal crosssection with a diameter of 3.4 mm, 2) an area with a diameter of 4.5 mm, and 3) an area with a diameter of 7.5 mm. The selection of diameters is based on values used in the commercially available devices for WAI measurements.
Figure 6 Energy absorbance predicted by the model using different areas to compute Z_{tw}, together with measurement based data from [12, 18, 19, 17] for different age groups with the mean or median age in days given in parentheses. 
Some agreements can be found in all predictions and measurementbased data: At low frequencies absorbance increases with frequency, and a maximum value at about 2 kHz is followed by a notch between 3 Hz and 4 kHz. However, large differences can be seen in both, predictions and measurementbased data. As can be seen in the predictions, the reference area used for the tube wave impedance largely affects the value of the energy absorbance in the whole frequency range between 100 Hz and 10 kHz. It should be noted that these differences in energy absorbance are only the result for one single idealized (cylindrical) ear canal geometry. They do not specify something like a normative range since other ear canal geometries will result in other differences caused by the selected reference area. In [12, 17] an acoustic estimate of the ear canal area at the probe tip was used, and in [18, 19] a reference area with a diameter of 7.5 mm was used. It can be seen that the measurementbased data differ and that effects of age (e.g. the effect of compliant ear canal walls) can possibly not be distinguished from effects due to a mismatch in reference area. The model predictions suggest that, if the energy absorbance is used as the immittance measure of choice, it might be more valuable to look at the variation with frequency in a range from 1 to 6 kHz rather than to look at absolute values.
5 Discussion
The parametric electroacoustic model of young infants’ eardrum and ear canal impedances proposed in [1] has been extended to account for selected pathological middle ear conditions. Firstly, the condition of fluid in the middle ear, which is the most frequent pathological middle ear condition in young infants, has been considered in the model. It has been realized by a single factor x_{A} decreasing the effective eardrum area and the volume of the tympanic cavity. Secondly, the condition of negative pressure difference Δp_{0} between the middle ear cavities and the ear canal has been implemented. Comparisons between model predictions for a normal middle ear status and for these pathological middle ear conditions showed characteristic differences for all WAI measures, including quantities that have mostly been ignored, i.e. phase quantities. Furthermore, it was shown that different reference diameters used to compute the acoustic absorbance lead to large differences for the same ear.
5.1 Implications for WAI measurements
For those immitance measures which can easily be determined by acoustic measurements in the ear canal (Z_{ec} and R), the effects of the different pathological middle ear conditions showed large differences at frequencies between 600 Hz and 6 kHz. In part I [1] it was found that the ear canal properties (geometry and compliant walls) dominate Z_{ec} at frequencies below 1.5 kHz and above 4 kHz, therefore, the frequency range from 1.5 kHz to 4 kHz should be suited to detect pathological middle ear conditions in young infants’ ears. This is in agreement with results of studies in which WAI was measured on young infants’ ears classified to have either a normal or a pathological middle ear status [7, 18, 20]. In [18], the energy reflectance (R^{2}) measured on infants aged between 0.7 and 5.9 months (median 2.1 months) was compared. It was found that a discrimination between normal hearing and conductive hearing loss was possible at frequencies around 1.6 kHz. In [20], the absorbance (1 − R^{2}) was measured on infants aged from birth up to 4 months (mean 1.3 months). A mixedmodel analysis of variance (ANOVA) showed significant different mean absorbance values between the normal hearing group and combined groups of ears having a conductive or a mixed hearing loss at frequencies from 1 to 8 kHz. In [7], the ear canal impedance (Z_{ec}) was measured on infants aged between 0.5 and 4.8 months (mean 1.8 months). Characteristic differences of Z_{ec} between normal ears and ears with middle ear effusion were found in the frequency range from 1 to 5 kHz. All these studies show that discriminating between normal and pathological middle ears of young infants based on WAI seems to be possible. Therefore, the goal should be the specification of normative WAI data for young infants. However, as was shown in Section 4, reflectance measures are strongly sensitive to the choice of the reference area. In order to make WAI measures less dependent on this choice (and thus less dependent on the measurement device being used), impedance (or admittance) quantities which do not require area information should be used to arrive at normative data. When reflectance quantities are used in studies, it is essential that complex quantities are specified and that the assumed reference area is also specified to at least allow comparisons with other data.
5.2 Age dependency
The model initially proposed in [1] and extended in this paper targets young infants aged between 1 and 5 months. The parameter values are partly based on physiological data found in literature. However, the few physiological data available do not allow a more detailed age dependency to be implemented yet. Comparisons of model predictions have been made with ear canal impedances measured on infants aged between 0.5 and 4.8 months. Our model does not account for age dependent effects within these age range yet.
Some agedependent WAI data can be found in the literature. In [12] absorbance values for the age groups of 1, 3, and 6 months showed that up to about 630 Hz the absorbance significantly decreases with increasing age. This was explained by a decrease of the effects due to the soft and flexible ear canal walls. In [19], absorbance values for the age groups roughly at 0.5, 2, 3, 4, 5 and 6 months showed that below about 500 Hz the absorbance slightly decreases with increasing age. At high frequencies around 3–4 kHz, the absorbance increases with increasing age. A comparison of absorbance values for age groups of 1 month and 6 months shows that an absorbance decreasing with increasing age at low frequencies was found in [12, 17, 19]. However, in [12] this lowfrequencybehavior was observed up to about 2 kHz, in [19] this was only true up to 500 Hz. In [17], in turn, the decreasing absorbance with increasing age was observed in the whole frequency range, but in [12, 19] an absorbance increasing with increasing age was observed at frequencies around 3–4 kHz. It can be concluded that: 1) effects caused by the soft and flexible ear canal walls decrease in the first months of life. 2) age dependency at high frequencies around 3–4 kHz can be expected. 3) unfortunately, the results of various studies in which absorbance values were determined for age groups contradict each other.
Furthermore, in [17] median absorbance values for newborns and for infants aged 1, 6, 9, and 12 months were published. Significant differences were found among the group of newborns, the age group of 1 month and the group 6–12 months. For clinical applications, the authors recommended to use separate normative references for these age groups. Therefore, in the future, an extension of our model to newborns might be valuable for the application of WAI in combination with the universal newborn hearing screening (UNHS). In this context, the effects of fluid in the middle ear are of special interest because UNHStests can be affected if amniotic fluid is still present in the middle ear shortly after birth.
6 Concluding remarks
In this paper, the parametric electroacoustic model of eardrum and ear canal impedances of young infants [1] was extended to account for specific pathological middle ear conditions:
The effect of fluid in the middle ear on Z_{ec} was modeled by a single factor x_{A} decreasing the effective eardrum area and the volume of the tympanic cavity. A factor of about 1/5 showed a good estimation of the effects of fluid in the middle ear observed in measurements on infants’ ears aged between 0.5 and 4.8 months.
For the pathological middle ear condition of negative pressure difference Δp_{0} between the middle ear cavities and the ear canal, a modeling approach was proposed. Characteristic effects in the modeled Z_{ec} caused by a negative Δp_{0} were found in the medium frequency range. At about 1.1 kHz, a local magnitude maximum appeared if Δp_{0} got negative. The increase of the phase value between 1.2 kHz and 2.5 kHz was shifted to higher frequencies. A confirmation of these effects by measurements was not yet possible due to a lack of available measurement data involving negative tympanic pressures. This could be part of future work.
Comparisons between the middle ear states normal, fluid in the middle ear and static pressure difference between ear canal and middle ear showed characteristic differences in all relevant immitance measures predicted with the model. Furthermore, it was shown that different reference diameters which are used in different measurement devices to compute the absorbance or energy reflectance lead to large differences in these immitance measures. Hence, the results are not comparable and should not be used to define normative data. Instead, quantities that do not require area information should be used, such as the acoustic impedance.
In the future, agedependent adaptations of the model could be valuable, especially to cover newborns. A further pathological condition to be included might be an oedematous middle ear. Furthermore, a middle ear classifier based on impedance (both magnitude and phase) will be developed.
Conflict of interest
The authors declare no conflict of interest.
Data availability statement
An implementation of the complete model is available on GitHub, under the reference https://github.com/tobiassankowsky/acoustic_impedance_infant_ear.
Acknowledgments
We would like to thank the two anonymous reviewers for their thoughtful comments on an earlier version of the manuscript. This work was partly funded by the Jade University’s research program Jade2Pro, partially supported by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – ProjectID 352015383 – SFB 1330/2 C1 and partially supported by the governmental funding initiative zukunft.niedersachsen of the Lower Saxony Ministry for Science and Culture, project “Datadriven health (DEAL)”.
References
 T. SankowskyRothe, S. van de Par, M. Blau: Parametric model of young infants’ eardrum and ear canal impedances supporting immittance measurement results. Part I: Development of the model. Acta Acustica 6 (2022) 53. [Google Scholar]
 M.P. Feeney, L.L. Hunter, J. Kei, D.J. Lilly, R.H. Margolis, H.H. Nakajima, S.T. Neely, B.A. Prieve, J.J. Rosowski, C.A. Sanford, K.S. Schairer, N. Shahnaz, S. Stenfelt, S.E. Voss: Consensus statement. Ear and Hearing 34 (2013) 78s–79s. [Google Scholar]
 C.D. Marchant, P.A. Shurin, V.A. Turczyk, D.E. Wasikowski, M.A. Tutihasi, S.E. Kinney: Course and outcome of otitis media in earlyinfancy: A prospective study. The Journal of Pediatrics 104 (1984) 826–831. [Google Scholar]
 J.L. Paradise, H.E. Rockette, D.K. Colborn, B.S. Bernard, C.G. Smith, M. KursLasky, J.E. Janosky: Otitis media in 2253 Pittsburgharea infants: Prevalence and risk factors during the first two years of life. Pediatrics 99 (1997) 318–333. [Google Scholar]
 S. Hoth: Audiometrie – Die Untersuchung des Gehörs und seine technische Versorgung, in: R. Kramme (Ed.), Medizintechnik: Verfahren – Systeme – Informationsverarbeitung, 4th edn., Springer, Berlin, Heidelberg, pp. 2011, 217–270. ISBN: 9783642161872. [Google Scholar]
 J.J.J. Dirckx, Y. Marcusohn, M.L. Gaihede: Quasistatic pressures in the middle ear cleft, in: S. Puria, R.R. Fay, A.N. Popper (Eds.), The middle ear, Springer, New York, 2013, pp. 93–133. ISBN: 9781461465911. [Google Scholar]
 T. SankowskyRothe, A. Becker, K. Plotz, R. Schönfeld, A. Radeloff, S. Van de Par, M. Blau: Acoustic input impedance of infants with normal and pathological middle ear, in Proceedings of the ICA 2019 and EAA Euroregio. 23rd International Congress on Acoustics, integrating 4th EAA Euroregio 2019 (Sept. 2019), Aachen, Germany, 2019. ISBN: 9783939296157. [Google Scholar]
 A. Stirnemann, H. Graf, H. Meier: Akustische Impedanzmessungen in der Hörgerätetechnik, in Fortschritte der Akustik DAGA 2003. DEGA, Berlin, 2003, pp. 496–497. [Google Scholar]
 M. Blau, T. Sankowsky, P. Roeske, H. Mojallal, M. Teschner, C. Thiele: Prediction of the sound pressure at the ear drum in occluded human cadaver ears. Acta Acustica united with Acustica 96 (2010) 554–566. [Google Scholar]
 R.Z. Gan, X. Wang: Multifield coupled finite element analysis for sound transmission in otitis media with effusion. The Journal of the Acoustical Society of America 122 (2007) 3527–3538. [Google Scholar]
 X. Wang, D.H. Keefe, R.Z. Gan: Predictions of middleear and passive cochlear mechanics using a finite element model of the pediatric ear. The Journal of the Acoustical Society of America 139 (2016) 1735–1746. [Google Scholar]
 D.H. Keefe, J.C. Bulen, K.H. Arehart, E.M. Burns: Earcanal impedance and reflection coefficient in human infants and adults. The Journal of the Acoustical Society of America 94 (1993) 2617–2638. [Google Scholar]
 T. SankowskyRothe: Parametric model of young infants’ eardrum and ear canal acoustic input impedances (version v1.0) [Code]. 2022. https://github.com/tobiassankowsky/acoustic_impedance_infant_ear. [Google Scholar]
 A. Lenk: Elektromechanische Systeme Band 2. Systeme mit verteilten Parametern. VEB Verlag Technik, Berlin, 1977. [Google Scholar]
 V.D. da Silva: Mechanics and strength of materials. Springer, Berlin, Heidelberg, 2006. [Google Scholar]
 D.H. Keefe, L.L. Hunter, M. Patrick Feeney, D. F. Fitzpatrick: Procedures for ambientpressure and tympanometric tests of aural acoustic reflectance and admittance in human infants and adults. The Journal of the Acoustical Society of America 138 (2015) 3625–3653. [Google Scholar]
 L.L. Hunter, D.H. Keefe, M.P. Feeney, D.F. Fitzpatrick, L. Lin: Longitudinal development of wideband reflectance tympanometry in normal and atrisk infants. Hearing Research 340 (2016) 3–14. [Google Scholar]
 B.A. Prieve, K.R. Vander Werff, J.L. Preston, L. Georgantas: Identification of conductive hearing loss in young infants using tympanometry and wideband reflectance. Ear and Hearing 34 (2013) 168–178. [Google Scholar]
 N. Shahnaz, A. Cai, L. Qi: Understanding the developmental course of the acoustic properties of the human outer and middle ear over the first 6 months of life by using a longitudinal analysis of power reflectance at ambient pressure. Journal of the American Academy of Audiology 25 (2014) 495–511. [Google Scholar]
 C.M. Blankenship, L.L. Hunter, D.H. Keefe, M.P. Feeney, D.K. Brown, A. McCune, D.F. Fitzpatrick, L. Lin: Optimizing clinical interpretation of distortion product otoacoustic emissions in infants. Ear and Hearing 39 (2018) 1075–1090. [Google Scholar]
Cite this article as: SankowskyRothe T. van de Par S. & Blau M. 2023. Parametric model of young infants’ eardrum and ear canal impedances supporting immittance measurement results. Part II: Prediction of eardrum and ear canal impedances for frequent pathological middle ear conditions. Acta Acustica, 7, 21.
All Figures
Figure 1 First approach to model the effects of fluid in the middle ear. Left: Acoustic input impedance at the eardrum Z_{D} and eardrum acoustic shunt impedance Z_{ac} for different factors of eardrum area. Middle: Ear canal impedance for different factors of eardrum area resulting from the model using an ear canal radius of 1.7 mm and an ear canal length of 14 mm. Right: Ear canal impedances measured in infants’ ears with middle ear effusion from [7]. 

In the text 
Figure 2 Final approach to model the effects of fluid in the middle ear. Left: Acoustic input impedance at the eardrum Z_{D} and eardrum acoustic shunt impedance Z_{ac} for different factors of eardrum area. Middle: Ear canal impedance for different factors of eardrum area resulting from the model using an ear canal radius of 1.7 mm and an ear canal length of 14 mm. Right: Ear canal impedances measured in infants’ ears with middle ear effusion from [7]. 

In the text 
Figure 3 Final approach to model the effects of fluid in the middle ear. Ear canal impedance for a factor of x_{A} = 0.2 eardrum area resulting from the model using an ear canal radius of 1.7 mm and an ear canal length of 14 mm together with all ear canal impedance measurements on infants’ ears with middle ear effusion from [7]. 

In the text 
Figure 4 Modeling of the effect of negative pressure difference between ear canal and middle ear using a Young’s modulus of E = 100 MPa. Left: Acoustic input impedance at the eardrum Z_{D} and eardrum acoustic shunt impedance Z_{ac} for different pressure differences Δp_{0} in kPa between ear canal and middle ear. Right: Ear canal impedance for different pressure differences Δp_{0} in kPa resulting from the model using an ear canal radius of 1.7 mm and an ear canal length of 14 mm, together with ear canal impedances from [7] measured in infants’ ears where the tympanometric peak pressure was smaller −1 kPa (−100 daPa). 

In the text 
Figure 5 Comparison of predicted immittance measures for ears with normal middle ear, fluid in the middle (x_{A} = 0.2), and negative pressure difference between middle ear and ear canal (Δp = −2500 Pa). Left column: acoustic input impedance at the eardrum; second column: input impedance of the ear; third column: magnitude and group delay of the reflectance; right column top: energy reflectance; right column bottom: energy absorbance. 

In the text 
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